Zinc Saves Kids

450,000 children are at risk of dying every year due to the impact of zinc deficiency on diarrhea, pneumonia, and malaria. A few extra milligrams of zinc every day can make a huge difference. Zinc-containing supplements are a quick and easy, effective and inexpensive remedy.

Video from IZA – International Zinc Association (2011). CONEM is an associate member of IZA.

 

Pneumonia Wonder Drug: Zinc Saves Lives

Respiratory tract infections, including pneumonia, are the most common cause of death in children under the age of five. In a study looking at children given standard antibiotic therapy, new research published in BioMed Central’s open access journal BMC Medicine shows how zinc supplements drastically improved children’s chances of surviving the infection. The increase in survival due to zinc (on top of antibiotics) was even greater for HIV infected children.

In a double-blind, randomized, placebo-controlled trial, 350 children, aged from six months to five years old, were treated with standard antibiotic therapy at Mulago Hospital. Half the children were given zinc and the other half a placebo.

The researchers from Makerere University found that while there was no difference between zinc and placebo in the time it took to recover from the infection (measured by time it took to return to a normal temperature, reparatory rate, and oxygen saturation) the risk of death between the groups was very different. 4% of the children taking zinc died compared to 12% of the children without zinc. This means that an extra eight out of 100 children could have been saved by taking zinc. Among the HIV infected children, this rose to 26 out of every 100.

Prof James Tumwine explained, “Zinc is known to bolster the immune system and zinc deficiency is rife all over the developed and developing, world. In Uganda, where this study was performed, zinc deficiency in some areas can be as high as 70%. We would only need to give 13 of these children with pneumonia zinc on top of their antibiotics to save one life. This equates to about 4 USD – a small price to pay.”

 

Reference

Srinivasan MG, Ndeezi G, Mboijana CK, Kiguli S, Bimenya GS, Nankabirwa V, Tumwine JK. Zinc adjunct therapy reduces case fatality in severe childhood pneumonia: a randomized double blind placebo-controlled trial. BMC Med 2012; 10: 14.

 

The Heresy Of Linus Pauling: Vitamin C

The heresy of Linus Pauling (1901 — 1994) was that he claimed a range of diseases could be cured by taking large amounts of vitamin C. He was condemned until a few years ago when other scientists began to have second thoughts.

Heretic: Linus Pauling

The last to be made about double Nobel Laureate Dr Linus Pauling, this film was shot about a year before he died in 1994. It chronicles how the world of science, having accoladed him for his breakthrough discoveries about the fundamental chemistry of molecules, later derided him for his experiments on – and championing of – the health benefits of high doses of Vitamin C.

BBC Heretic Series. Ep. 2: Linus Pauling, Vitamin C. 1994.

 

Professional Perspectives on Water Fluoridation

Learn why over 2,000 scientific, medical and environmental professionals are calling for an end to fluoridation worldwide. This video is produced by Fluoride Action Network in 2009

“One of the recommendations I’ve made is, because we now know that fluoride doesn’t need to be swallowed, that the public has to be informed. They should be told that it doesn’t work by swallowing it.”
-Dr. Hardy Limeback- National Research Council Panelist

“As far as I can see, there’s no doubt that the intake of fluoridated water is going to interrupt basic functions of nerve cells in the brain, and this is certainly not going to be to the benefit of anybody.”
-Dr. Robert Isaacson- National Research Council Panelist

“Fluoridation is against all modern principles of pharmacology. It’s obsolete. I don’t think anybody, not a single dentist, would bring up this queston in Sweden anymore.”
-Dr. Arvid Carlsson- Nobel Laurete in Medicine (2000)

Special Features:
Dr. Bill Osmunson on Water Fluoridation (5 min)
Dr. Vyvyan Howard on Fluoride & the brain (4 min)
Fluoride warning for kidney patients (3 min)
An Environmentalist speaks out on Fluoridation (6 min)

Cardiovascular Disease

A Unified Theory of The Cause & Treatment

The two-time unshared Nobel Prize recipient Linus Pauling (1901 – 1994) and the German medical doctor Matthias Rath (born 1955) presented in 1989 a new theory of cardiovascular disease.

They hypothesized that heart disease is a manifestation of chronic scurvy, and atherosclerotic plaque is a mechanism evolved to repair or patch blood vessels and arteries damaged by chronic vitamin C deficiency. Plaque deposits found in human aortas are made up of a blood lipid called lipoprotein(a).

The solution Pauling and Rath suggested on this problem were that high dosages of vitamin C and lysine in combination neutralize lipoprotein(a). This may according to the researchers prevent and cure cardiovascular disease. The following is a video with Linus Pauling from 1993. The video has an introduction by Patrick Holford.

 

 

Read More

Rath M, Pauling L. Solution to the Puzzle of Human Cardiovascular Disease: Its Primary Cause is Ascorbate deficiency, leading to the deposition of lipoprotein(a) and fibrinogen/fibrin in the vascular wall. J Orthomol Med 1991; 6(3-4): 125-34.

Rath M, Pauling L. A unified theory of human cardiovascular disease leading the way to abolition of this disease as a cause for human mortality. J Orthomol Med 1992; 7(1): 5-12.

In Small Doses: Arsenic

This is a short movie, made by Dartmouth College in 2009, about the risks associated with exposure to potentially harmful amounts of arsenic in private well water, particularly in New Hampshire and New England.

Nutritional Epigenetics

This little video beautifully explains the concept of nutritional epigenetics. Working with international researchers, we published in 2013 a review on this topic:

Jalili M, Pati S, Rath B, Bjørklund G, Singh RB. Effect of Diet and Nutrients on Molecular Mechanism of Gene Expression Mediated by Nuclear Receptor and Epigenetic Modulation. Open Nutra J 2013;6:27-34.

The Interwoven Global Epidemics of Mercury Toxicity and Autism

In October 2017, Robert F. Kennedy Jr. published an article on the website of the World Mercury Project about one of CONEM’s studies (1). Kennedy is the son of former New York senator and U.S. attorney general Robert F. Kennedy and nephew of former President John F. Kennedy. He is an attorney, environmental activist and syndicated talk radio host. 

The Interwoven Global Epidemics of Mercury Toxicity and Autism

Metals wreak havoc on living systems, including humans, animals and plants alike. RFK, Jr. discusses a new review article in Environmental Research and pulls together a wide body of literature with the aim of summing up current research and emerging trends about the global epidemics of toxicity and autism.

Reference

1. Bjørklund G, Dadar M, Mutter J, Aaseth J. The toxicology of mercury: Current research and emerging trends. Environ Res 2017; 159: 545-554.

 

Dental Amalgams and Chronic Disease

Working with a team of American researchers, we published in 2014 a review about the association between dental amalgams and chronic disease (1). The following is a summary:

“The purpose of this review is to examine the evidence for a relationship between mercury (Hg) exposure from dental amalgams and certain idiopathic chronic illnesses–chronic fatigue syndrome (CFS), fibromyalgia (FM), depression, anxiety, and suicide. Dental amalgam is a commonly used dental restorative material that contains approximately 50% elemental mercury (Hg0) by weight and releases Hg0 vapor. Studies have shown that chronic Hg exposure from various sources including dental amalgams is associated with numerous health complaints, including fatigue, anxiety, and depression–and these are among the main symptoms that are associated with CFS and FM. In addition, several studies have shown that the removal of amalgams is associated with improvement in these symptoms. Although the issue of amalgam safety is still under debate, the preponderance of evidence suggests that Hg exposure from dental amalgams may cause or contribute to many chronic conditions. Thus, consideration of Hg toxicity may be central to the effective clinical investigation of many chronic illnesses, particularly those involving fatigue and depression.”

– Geir Bjørklund

Reference

1. Kern JK, Geier DA, Bjørklund G, King PG, Homme KG, Haley BE, Sykes LK, Geier MR. Evidence supporting a link between dental amalgams and chronic illness, fatigue, depression, anxiety, and suicide. Neuro Endocrinol Lett 2014; 35: 537-552.

The Rise of the Antibiotic-Resistant Superbug

Infographic of the antibiotic-resistant diseases.

Zinc, Copper, and Autism Spectrum Disorder

Joint Research

Research indicates that children with autism spectrum disorder (ASD) appear to be at risk for zinc (Zn) deficiency, copper (Cu) toxicity, and often disturbed metallothionein system functioning (1-4). Working with international researchers, the following is a summary of our work.

Li et al. (2014) investigated the serum levels of Zn and Cu in 60 Chinese children with ASD (48 boys, 12 girls) and a control group of 60 healthy sex-matched and age-matched individuals (2). The researchers also evaluated the autism severity using the Childhood Autism Rating Scale (CARS) score. The mean serum Zn levels and Zn/Cu ratio in the study were significantly lower in the ASD children compared with the control group (P<0.001). At the same, the serum Cu levels were significantly higher in the ASD children compared with the control group (P<0.001). It was in the study found a significant negative association between the Zn/Cu ratio and CARS scores (r=-0.345, P=0.007) (2).

Macedoni-Lukšič et al. (2015) determined the serum levels of Zn and Cu in a group of Slovenian children with ASD (N = 52, average age = 6.2 years) and a control group of children with other neurological disorders (N = 22, average age = 6.6 years), matched in terms of intellectual abilities (3). Compared to the control group, the ASD group had significantly elevated serum Cu/Zn ratio (95% confidence interval for children with ASD=1.86-2.26; 95% confidence interval for the control group=1.51-1.88) (3).

Crăciun et al. (2016) investigated the levels of Zn and Cu in whole blood, as well as the Cu/Zn ratio in a group of 28 Romanian ASD children. No significant difference in whole blood Cu was observed. However, Cu/Zn ratio was ~15 % (p = 0.008) higher in ASD children than that in the control ones. The results of the study may be indicative of Zn deficiency in ASD children (4).

In conclusion, our research suggests that providing Zn to ASD children may be an important component of a treatment protocol, especially in children with Zn deficiency (1-4). Mercury accumulation may occur as a cause or consequence of metallothionein dysfunction in ASD children, which may be one of the causes of Zn deficiency. Metallothioneins are proteins with important functions in metal metabolism and protection. It is important to monitor and follow the values for both Cu and Zn together during Zn therapy because these two trace elements are both antagonists in function, and essential for living cells (1).

– Geir Bjørklund

 

References

1. Bjørklund G. The role of zinc and copper in autism spectrum disorders. Acta Neurobiol Exp 2013; 73: 225–236.

2. Li SO, Wang JL, Bjørklund G, Zhao WN, Yin CH. Serum copper and zinc levels in individuals with autism spectrum disorders. Neuroreport 2014; 25: 1216-1220.

3. Macedoni-Lukšič M, Gosar D, Bjørklund G, Oražem J, Kodrič J, Lešnik-Musek P, Zupančič M, France-Štiglic A, Sešek-Briški A, Neubauer D, Osredkar J. Levels of metals in the blood and specific porphyrins in the urine in children with autism spectrum disorders. Biol Trace Elem Res 2015; 163: 2-10.

4. Crăciun EC, Bjørklund G, Tinkov AA, Urbina MA, Skalny AV, Rad F, Dronca E. Evaluation of whole blood zinc and copper levels in children with autism spectrum disorder. Metab Brain Dis 2016; 31: 887-890.