CONEM collaborates in research and publishes research and review articles in international peer-reviewed journals. The publications are sorted alphabetically by year and title.

Publications 2018

*Bias and Misleading Concepts in an Arnica Research Study. Comments to Improve Experimental Homeopathy
Chirumbolo S, Bjørklund G
J Ayurveda Integr Med. doi: 10.1016/j.jaim.2017.01.014

Publications 2017

Assessment of Gender and Age Effects on Serum and Hair Trace Element Levels in Children with Autism Spectrum Disorder 
Skalny AV, Simashkova NV, Skalnaya AA, Klyushnik TP, Bjørklund G, Skalnaya MG, Tinkov AA
Metab Brain Dis 2017. doi: 10.1007/s11011-017-0056-7. PubMed PMID: 28664504

Chrysin and Baicalin in Diabetic Nephropathy
Chirumbolo S, Bjørklund G
Environ Toxicol Pharmacol 2017;51:156-157. PubMed PMID: 28262431 (IF 2.187)

Concerns about Environmental Mercury Toxicity: do we forget something else?
Bjørklund G, Bengtsson U, Chirumbolo S, Kern JK
Environ Res 2017;152:514-516. PubMed PMID: 27616662 (IF 3.835)

Dietary Adequacy of Egyptian Children with Autism Spectrum Disorder Compared to Healthy Developing Children
Meguid NA, Anwar M, Bjørklund G, Hashish A, Chirumbolo S, Hemimi M, Sultan E
Metab Brain Dis 2017;32:607-615. PubMed PMID: 28074329 (IF 2.603)

*Effects of Arsenic Toxicity beyond Epigenetic Modifications
Bjørklund G, Aaseth J, Chirumbolo S, Urbina MA, Uddin R
Environ Geochem Health 2017. doi: 10.1007/s10653-017-9967-9. PubMed PMID: 28484874 (IF 2.079)

Extended Consensus on Blood Pressure Variability beyond Blood Pressure for Management of Hypertension
Singh RB, Hristova K, Bjørklund G, Fedacko J, Chirumbolo S, Pella D
J Am Soc Hypertens 2017;11:6-9. PubMed PMID: 28040405 (IF 2.656)

Flavonoids as Detoxifying and Pro-Survival Agents: What’s New?
Bjørklund G, Dadar M, Chirumbolo S, Lysiuk R
Food Chem Toxicol 2017. Accepted 22.10.2017 (IF 3.778)

Hair Toxic and Essential Trace Elements in Children with Autism Spectrum Disorder
Skalny AV, Klyushnik TP, Simashkova NV, Grabeklis AR, Bjørklund G, Skalnaya MG, Nikonorov AA, Tinkov AA
Metab Brain Dis 2017;32:195-202. PubMed PMID: 27581303 (IF 2.603)

Histone Deacetylase Inhibitors, Thimerosal, and Autism Spectrum Disorder
Bjørklund G, Chirumbolo S, Geier DA, Kern JK, Geier MR
Environ Res 2017;156:843–844. PubMed PMID: 28410622 (IF 3.835)

*Homeopathic Arnica from Boiron and Post-Operative Bleeding in Mastectomized Women in Milan: Statistical Flaws and Bias to be Addressed
Chirumbolo S, Bjørklund G
J Tradit Complement Med 2017. doi: 10.1016/j.jtcme.2017.05.001.

Homeopathic Potencies of Arnica Montana L. Change Gene Expression in a THP-1 Cell Line in Vitro Model: the Role of Ethanol as a Possible Confounder and Statistical Bias
Chirumbolo S, Bjørklund G
J Integr Med 2017;15:255-264.PubMed PMID: 28659229

*How Important is Tryptophan in Human Health?
Kałużna-Czaplińska J, Gątarek P, Salvatore Chirumbolo, Chartrand MS, Bjørklund G
Crit Rev Food Sci Nutr 2017. Accepted (IF 6.077)

Imaging Techniques: New Avenues in Cancer Gene and Cell Therapy
Saadatpour Z, Rezaei A, Ebrahimnejad H, Baghaie B, Bjørklund G, Chartrand M, Sahebkar A, Morovati H, Mirzaei HR, Mirzaei H
Cancer Gene Ther 2017;24:1-5. PubMed PMID: 27834357 (IF 2.532)

Interactions of Iron with Manganese, Zinc, Chromium, and Selenium as Related to Prophylaxis and Treatment of Iron Deficiency
Bjørklund G, Aaseth J, Skalny AV, Suliburska J, Skalnaya MG, Nikonorov AA, Tinkov AA
J Trace Elem Med Biol 2017;41:41-53. PubMed PMID: (IF 2.550)

Manganese Exposure and Neurotoxic Effects in Children
Bjørklund G, Chartrand MS, Aaseth J
Environ Res 2017;155:380-384. PubMed PMID: 28282629  (IF 3.835)

May Traffic Air Pollution be Involved in Autism Spectrum Disorder?
Chirumbolo S, Bjørklund G, Urbina MA
Environ Res 2017;154:57-59. PubMed PMID: 28038434 (IF 3.835)

Metal Chelators and Neurotoxicity: Lead, Mercury, and Arsenic
Bjørklund G, Mutter J, Aaseth J
Arch Toxicol. Accepted 19.10.2017

Molecular and Physiological Roles of Estrogen Receptor
Al-Khatib AJ, Ali Shotar A, Bjørklund G
J Pharm Pharmaceutics 2017;4(1): 1- 9. doi:10.15436/2377-1313.17.021

*Molecular Imaging and Cancer Gene Therapy
Saadatpour Z, Bjørklund G, Chirumbolo S, Alimohammadi M, Ehsani H, Ebrahiminejad H, Pourghadamyari H, Mirzaei HR, Sahebkar A, Mirzaei H, Keshavarzi M
Cancer Gene Ther. 2016 Nov 18. doi:10.1038/cgt.2016.62. PubMed PMID: 27857058 (IF 2.532)

Molecular Interaction between Mercury and Selenium in Neurotoxicity
Bjørklund G, Aaseth J, Ajsuvakova OP, Nikonorov AA, Skalny AV, Skalnaya MG, Tinkov AA
Coord Chem Rev 2017;332:30-37 (IF 12.994)

PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of Xenobiotics and Hormesis in Cell Survival and Homeostasis
Chirumbolo S, Bjørklund G
Int J Mol Sci 2017;18:165. doi:10.3390/ijms18010165. PubMed PMID: 28098843 (IF 3.257)

*Plasma alpha-L-fucosidase Activity in Chronic Inflammation and Autoimmune Disorders in a Pediatric Cohort of Hospitalized Patients
Endreffy I, Bjørklund G, Szerafin L, Urbina MA, Chirumbolo S, Endreffy E
Immunologic Research 2017. doi: 10.1007/s12026-017-8943-x. PubMed PMID: (IF 2.905)

Predictive Value of Selected Biomarkers Related to Metabolism and Oxidative Stress in Children with Autism Spectrum Disorder
El-Ansary A, Bjørklund G, Chirumbolo S, Alnakhli OM
Metab Brain Dis 2017;32:1209-1221. PubMed PMID: 28497358 (IF 2.603) 

Pyrethroid Pesticides in the Autophagy/Apoptosis Balance: Role in Adipocyte Lipidogenesis
Chirumbolo S, Bjørklund G
Food Chem Toxicol 2017;106:568-569. PubMed PMID: 28377267 (IF 3.584)

*Randomized-Controlled Trial of Vitamin D Supplementation in Children with Autism Spectrum Disorder
Saad K, Abdel-rahman AA, Elserogy YM, Al-Atram AA, El-Houfey AA, Othman HAK, Bjørklund G, Jia F, Urbina MA, Abo-Elela MGM, Ahmad FA, Abd El-Baseer KA, Ahmed AE, Abdel-Salam AM
J Child Psychol Psychiatry. 2016 Nov 21. doi:10.1111/jcpp.12652. PubMed PMID: 27868194 (IF 6.615)

Recent Aspects of Uranium Toxicology in Medical Geology
Bjørklund G, Christophersen OA, Chirumbolo S, Selinus S, Aaseth J
Environ Res 2017;156:526-533. PubMed PMID: 28431380 (IF 3.835)

Relationship between Selenium, Lead, and Mercury in Red Blood Cells of Saudi Autistic Children 
El-Ansary A, Bjørklund G, Tinkov AA, Skalny A, Al Dera HS
Metab Brain Dis. 2017;32:1073-1080. PubMed PMID: 28326463 (IF 2.603)

Role of Oxidative Stress and Antioxidants in Daily Nutrition and Human Health
Bjørklund G, Chirumbolo S
Nutrition 2017;33:311-321. PubMed PMID: 27746034 (IF 2.839)

The Antinociceptive Activity of Geraniol
Chirumbolo S, Bjørklund G
Basic Clin Pharmacol Toxicol 2017;120:105-107. PubMed PMID: 28000392 (IF 3.097)

The Breakthroughs of Karl Folkers in Biochemistry and Human Nutrition
Bjørklund G, Chartrand M
J Nutr Disorders Ther 2017;7:2. doi: 10.4172/2161-0509.1000213

The Role of Cadmium in Obesity and Diabetes
Tinkov AA, Filippini T, Ajsuvakova OP, Aaseth J, Gluhcheva YG, Ivanova JM, Bjørklund G, Skalnaya MG, Gatiatulina ER, Popova EV, Nemereshina ON, Vinceti M, Skalny AV
Sci Total Environ 2017;601–602:741–755. PubMed PMID: 28577409 (IF 3.976)

The Role of Intestinal Microbiota in Obesity
Kałużna-Czaplińska J, Gątarek P, Chartrand MS, Dadar M, Bjørklund G
Trends Food Sci Technol. Accepted 19.10.2017

The Role of Vitamin D in the Immune System as a Pro-survival Molecule 
Chirumbolo S, Bjørklund G, Sboarina A, Vella A
Clinical Therapeutics 2017;39:894-916. PubMed PMID: 28438353 (IF 2.925)

The Sesquiterpene α-bisabolol in the Adipocyte-cancer Desmoplastic Crosstalk: does it have an Action on Epithelial-mesenchymal Transition Mechanisms?
Chirumbolo S, Bjørklund G
Int J Clin Oncol 2017;22:222–228. PubMed PMID: 27942879 (IF 1.806)

The Toxicology of Mercury: Current Research and Emerging Trends
Bjørklund G, Dadar M, Mutter J, Aaseth J
Environ Res 2017; In Press (IF 3.835)

*Tryptophan Status in Autism Spectrum Disorder and the Influence of Supplementation on Its Level
Kałużna-Czaplińska J, Jóźwik-Pruska J, Chirumbolo S, Bjørklund G
Metab Brain Dis 2017. doi: 10.1007/s11011-017-0045-x

*Using a CD45dim/CD123bright/HLA-DRneg phenotyping protocol to gate basophils in FC for airway allergy. CD123 does not decrease
Chirumbolo S, Bjørklund G, Vella A
Adv Respir Med 2017; In press

Vaccination is Fundamental but Can It Escape from a More Insightful and Critical Information about Its Action? 
Chirumbolo S, Bjørklund G
Environ Toxicol Pharmacol 2017;55:8–13. PubMed PMID: (IF 2.313)

Publications 2016

Acid Glycosaminoglycan (aGAG) Excretion is increased in Children with Autism Spectrum Disorder, and it can be controlled by Diet
Endreffy I, Bjørklund G, Dicső F, Urbina MA, Endreffy E
Metab Brain Dis 2016;31:273-278. PubMed PMID: 26464064 – ResearchGate (IF 2.603)

Altered Urinary Porphyrins and Mercury Exposure as Biomarkers for Autism Severity in Egyptian Children with Autism Spectrum Disorder
Khaled EM, Meguid NA, Bjørklund G, Gouda A, Bahary MH, Hashish A, Sallam NM, Chirumbolo S, El-Bana MA
Metab Brain Dis 2016;31:1419-1426. PubMed PMID: 27406246 (IF 2.603)

Can Wnt5a and Wnt Non-Canonical Pathways Really Mediate Adipocyte Dedifferentiation in a Tumor Microenvironment?
Chirumbolo S, Bjørklund G
Eur J Cancer 2016;64:96-100. PubMed PMID: 27391920 (IF 6.163)

Commentary: Arnica Montana Effects on Gene Expression in a Human Macrophage Cell Line. Evaluation by Quantitative Real-Time PCR
Chirumbolo S, Bjørklund G
Front Immunol 2016;7:280. PubMed PMID: 27660630 (IF 5.695)

Commentary: Sulfur Dioxide Contributes to the Cardiac and Mitochondrial Dysfunction in Rats
Chirumbolo S, Bjørklund G
Front Cardiovasc Med 2016;3:15. doi:10.3389/fcvm.2016.00015

Commentary: The Flavonoid Baicalein Rescues Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer’s Disease
Chirumbolo S, Bjørklund G
Front Neurol 2016;7:141. doi:10.3389/fneur.2016.00141. PMID: 27618870

Evaluation of Whole Blood Zinc and Copper Levels in Children with Autism Spectrum Disorder
Crăciun EC, Bjørklund G, Tinkov AA, Urbina MA, Skalny AV, Rad F, Dronca E
Metab Brain Dis 2016;31:887-890. PubMed PMID: 27059237 (IF 2.603)

Immune Dysfunction and Neuroinflammation in Autism Spectrum Disorder
Bjørklund G, Saad K, Chirumbolo S, Kern JK, Geier DA, Geier MR, Urbina MA
Acta Neurobiol Exp (Wars) 2016;76:257-268. PubMed PMID: 28094817 (IF 1.708)

Mental and Spiritual Health and the Heart: A Viewpoint
Singh RB, Bjørklund G, Shastun S, Cornelissen G, Elkilany G, Agnieszka Wilczynska, De Meester F, Hristova K
World Heart J 2016;8:233-236. ResearchGate

Mercury as a Possible Link Between Maternal Obesity and Autism Spectrum Disorder
Skalny AV, Skalnaya MG, Bjørklund G, Nikonorov AA, Tinkov AA
Med Hypotheses 2016;91:90-94. PubMed PMID: 27142153 – ResearchGate (IF 1.136)

Nutritional and Environmental Influences on Autism Spectrum Disorder
Bjørklund G, Chartrand M
J Nutr Disorders The 2016;6(1):e123. doi:10.4172/2161-0509.1000e123

Red Seaweeds for Obesity Prevention?
Chirumbolo S, Bjørklund G
Food Chem Toxicol 2016; 94: 268-269 (IF 3.584)

Resveratrol and Cisplatin in a Malignant Mesothelioma Cell Model
Chirumbolo S, Bjørklund G
Food Chem Toxicol 2016;98(Pt B):308-309. PMID: 27856297 (IF 3.584)

The Levels of Blood Mercury and Inflammatory-related Neuropeptides in the Serum are correlated in Children with Autism Spectrum Disorder
Mostafa GA, Bjørklund G, Urbina MA, AL-Ayadhi LY
Metab Brain Dis 2016;31:593-599. PubMed PMID: 26738726ResearchGate (IF 2.603)

The Positive Association between Elevated Blood Lead Levels and Brain-specific Autoantibodies in Autistic Children from Low Lead-polluted Areas
Mostafa GA, Bjørklund G, Urbina MA, Al-Ayadhi LY
Metab Brain Dis 2016;31:1047-1054. PMID: 27250967 (IF 2.603)

Treatment Strategies in Alzheimer´s Disease: A Review with Focus on Selenium Supplementation 
Aaseth J, Alexander J, Bjørklund G, Hestad K, Dusek P, Roos PM, Alehagen U
Bometals 2016;29:827-839. PMID: 27530256 (IF 2.134)

Vitamin D Deficiency: A Global Health Problem
Bjørklund G
Peertechz J Environ Sci Toxicol 2016;1(1):023-024

Vitamin D Status in Autism Spectrum Disorders and the Efficacy of Vitamin D Supplementation in Autistic Children
Saad K, Abdel-rahman AA, Elserogy YM, Al-Atram AA, Cannell JJ, Bjørklund G, Abdel-Reheim MK, Othman HAK, El-Houfey AA, Hashem EA, Abd El-Aziz NHR, Abd El-Baseer KA, Ahmed AE, Ali AM
Nutr Neurosci 2016;19:346-351. PubMed PMID: 25876214 (IF 2.616)

Publications 2015

A Randomized, Placebo-Controlled Trial of Digestive Enzymes in Children with Autism Spectrum Disorders
Saad K, Eltayeb AA, Mohamad IL, Al-Atram AA, Elserogy Y, Bjørklund G, El-Houfey AA, Nicholson B
Clin Psychopharmacol Neurosci 2015;13:188-193. PubMed PMID: 26243847 – ResearchGate (IF 1.500)

ADHD, Autism and Neuroradiological Complications among Phenylketonuric Children in Upper Egypt
Saad K, Elserogy Y, Abdel Rahman AA, Al-Atram AA, Mohamad IL, ElMelegy TTH, Bjørklund G, El-Houfy AA
Acta Neurol Belg. 2015;115:657-663. PubMed PMID: 25576444 – ResearchGate (IF 1.495)

Clinical Use of the Metal Chelators Calcium Disodium Edetate, DMPS, and DMSA
Bjørklund G
Saudi J Kidney Dis Transpl 2015;26:611-612. PubMed PMID: 26022042

Diet and Atherosclerosis in Ancient Periods
Bjørklund G, Wilson DW, De Meester F, Takahashi T, Wilczynska A, Singh RB, Saboo B
World Heart J 2015;7(1):51-61

Increased Frequency of Delayed Type Hypersensitivity to Metals in Patients with Connective Tissue Disease
Stejskal V, Reynolds T, Bjørklund G
J Trace Elem Med Biol 2015;31:230–236. PubMed PMID: 25636536 (IF 2.550)

Levels of Metals in the Blood and Specific Porphyrins in the Urine in Children with Autism Spectrum Disorders
Macedoni-Lukšič M, Gosar D, Bjørklund G, Oražem J, Kodrič J, Lešnik-Musek P, Zupančič M, France-Štiglic A, Sešek-Briški A, Neubauer D, Osredkar J
Biol Trace Elem Res 2015;163:2-10. PubMed PMID: 25234471 – ResearchGate (IF 1.798)

Selenium as an Antidote in the Treatment of Mercury Intoxication
Bjørklund G
Biometals. 2015;28:605-614. PubMed PMID: 25947386 (IF 2.134)

Systematic Assessment of Research on Autism Spectrum Disorder and Mercury Reveals Conflicts of Interest and the Need for Transparency in Autism Research
Kern JK, Geier DA, Deth RC, Sykes LK, Hooker BS, Love JM, Bjørklund G, Chaigneau CG, Haley BE, Geier MR
Sci Eng Ethics 2015. doi:10.1007/s11948-015-9713-6. PubMed PMID: 26507205 (IF 1.454)

The Adjuvant Nutritional Intervention in Cancer (ANICA) Trial
Bjørklund G
Nutr Cancer 2015;67:1355-1358. PubMed PMID: 26473998 (IF 2.241)

Vitamin D Deficiency and its Associated Predictors among Patients Visiting Primary Health Care Center
Kassab M, Alkhatib AJ, Shotar A, Bjørklund G
Res J Biol Sci 2015;10(4):78-80

Publications 2014

Depression among Addictive Patients in Jordan
Alkhatib AJ, Bashir NA, Bjørklund G, Shotar AM, Rawashdeh WS , AlOmary M, Al-kresha R
Indian Research Journal of Pharmacy and Science 2014;1(3):10-18

Evidence Supporting a Link Between Dental Amalgams in Chronic Illness, Fatigue, Depression, Anxiety, and Suicide
Kern JK, Geier DA, Bjørklund G, King PG, Homme KG, Haley BE, Sykes LK, Geier MR
Neuro Endocrinol Lett 2014;35:537-552. PubMed PMID: 25617876 (IF 0.82)

Serum Copper and Zinc Levels in Individuals with Autism Spectrum Disorders
Li SO, Wang JL, Bjørklund G, Zhao WN, Yin CH
Neuroreport 2014;25:1216–1220. PubMed PMID: 25162784 – ResearchGate (IF 1.343)

The Role of Heat Shock Protein 90 in Human Reproduction
Alkhatib AJ, Hamadneh J, Bjørklund G, Alrasheidi SA
Res J Biol Sci 2014;9:161-164

Publications 2013

Effect of Diet and Nutrients on Molecular Mechanism of Gene Expression Mediated by Nuclear Receptor and Epigenetic Modulation
Jalili M, Pati S, Rath B, Bjørklund G, Singh RB
Open Nutra J 2013;6:27-34

Metal-Induced Inflammation Triggers Fibromyalgia in Metal-Allergic Patients
Stejskal V, Öckert K, Bjørklund G
Neuro Endocrinol Lett 2013;34:559-565. PubMed PMID: 24378456 (IF 0.82)

The Role of Zinc and Copper in Autism Spectrum Disorders
Bjørklund G
Acta Neurobiol Exp 2013;73:225–236. PubMed PMID: 23823984 (IF 1.708)

Manuscripts Submitted
Ongoing Projects